A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

BACKGROUND: Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Principais autores: Ramasamy, Viswanathan, Arora, Upasana, Shukla, Rahul, Poddar, Ankur, Shanmugam, Rajgokul K., White, Laura J., Mattocks, Melissa M., Raut, Rajendra, Perween, Ashiya, Tyagi, Poornima, de Silva, Aravinda M., Bhaumik, Siddhartha K., Kaja, Murali Krishna, Villinger, François, Ahmed, Rafi, Johnston, Robert E., Swaminathan, Sathyamangalam, Khanna, Navin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774828/
https://ncbi.nlm.nih.gov/pubmed/29309412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006191
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