A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

BACKGROUND: Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Ramasamy, Viswanathan, Arora, Upasana, Shukla, Rahul, Poddar, Ankur, Shanmugam, Rajgokul K., White, Laura J., Mattocks, Melissa M., Raut, Rajendra, Perween, Ashiya, Tyagi, Poornima, de Silva, Aravinda M., Bhaumik, Siddhartha K., Kaja, Murali Krishna, Villinger, François, Ahmed, Rafi, Johnston, Robert E., Swaminathan, Sathyamangalam, Khanna, Navin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774828/
https://ncbi.nlm.nih.gov/pubmed/29309412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006191
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