A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

BACKGROUND: Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their...

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Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Ramasamy, Viswanathan, Arora, Upasana, Shukla, Rahul, Poddar, Ankur, Shanmugam, Rajgokul K., White, Laura J., Mattocks, Melissa M., Raut, Rajendra, Perween, Ashiya, Tyagi, Poornima, de Silva, Aravinda M., Bhaumik, Siddhartha K., Kaja, Murali Krishna, Villinger, François, Ahmed, Rafi, Johnston, Robert E., Swaminathan, Sathyamangalam, Khanna, Navin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774828/
https://ncbi.nlm.nih.gov/pubmed/29309412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006191
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