Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

Development and binding affinity predictions of inhibitors targeting protein–protein interactions (PPI) still represent a major challenge in drug discovery efforts. This work reports application of a predictive non-empirical model of inhibitory activity for PPI inhibitors, exemplified here for small...

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Foilsithe in:Medchemcomm
Main Authors: Jedwabny, Wiktoria, Kłossowski, Szymon, Purohit, Trupta, Cierpicki, Tomasz, Grembecka, Jolanta, Dyguda-Kazimierowicz, Edyta
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2017
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774433/
https://ncbi.nlm.nih.gov/pubmed/29456828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00170c
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