Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice

We investigated the role of nuclear factor erythroid 2–related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal tubule cells (RPTCs) and in the development of systemic hypertension and kidney injury in diabetic Akita mice. We used adult male Akita Nrf2 knockout mic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Endocrinology
Prif Awduron: Zhao, Shuiling, Ghosh, Anindya, Lo, Chao-Sheng, Chenier, Isabelle, Scholey, James W., Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774246/
https://ncbi.nlm.nih.gov/pubmed/29211853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00752
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg