Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice

We investigated the role of nuclear factor erythroid 2–related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal tubule cells (RPTCs) and in the development of systemic hypertension and kidney injury in diabetic Akita mice. We used adult male Akita Nrf2 knockout mic...

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Publicado no:Endocrinology
Main Authors: Zhao, Shuiling, Ghosh, Anindya, Lo, Chao-Sheng, Chenier, Isabelle, Scholey, James W., Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774246/
https://ncbi.nlm.nih.gov/pubmed/29211853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00752
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