Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice

We investigated the effects of dual renin-angiotensin system (RAS) blockade on angiotensin-converting enzyme-2 (Ace2) expression, hypertension, and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in th...

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Hlavní autoři: Lo, Chao-Sheng, Liu, Fang, Shi, Yixuan, Maachi, Hasna, Chenier, Isabelle, Godin, Nicolas, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340935/
https://ncbi.nlm.nih.gov/pubmed/22205225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00340.2011
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