Angiotensin II Upregulates Sodium-Glucose Co-Transporter2 (SGLT2) Expression and SGLT2 Inhibitor Attenuates Ang II-Induced Hypertensive Renal Injury in Mice

Clinical trials indicate that sodium-glucose co-transporter 2 inhibitors (SGLT2i) improve kidney function, yet, the molecular regulation of SGLT2 expression is incompletely understood. Here, we investigated the role of the intrarenal renin-angiotensin-system (RAS) on SGLT2 expression. In adult non-d...

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Publicat a:Clin Sci (Lond)
Autors principals: Miyata, Kana N., Lo, Chao-Sheng, Zhao, Shuiling, Liao, Min-Chun, Pang, Yuchao, Chang, Shiao-Ying, Peng, Junzheng, Kretzler, Matthias, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S.D.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131957/
https://ncbi.nlm.nih.gov/pubmed/33822013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20210094
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