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Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter

Allostery plays a crucial role in the mechanism of neurotransmitter-sodium symporters, such as the human dopamine transporter. To investigate the molecular mechanism that couples the transport-associated inward release of the Na(+) ion from the Na2 site to intracellular gating, we applied a combinat...

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Foilsithe in:Biophys J
Main Authors: LeVine, Michael V., Cuendet, Michel A., Razavi, Asghar M., Khelashvili, George, Weinstein, Harel
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Biophysical Society 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773750/
https://ncbi.nlm.nih.gov/pubmed/29153319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.030
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