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NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT

Complex networks of interacting residues and microdomains in the structures of biomolecular systems underlie the reliable propagation of information from an input signal, such as the concentration of a ligand, to sites that generate the appropriate output signal, such as enzymatic activity. This inf...

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Detalhes bibliográficos
Main Authors: LeVine, Michael V., Weinstein, Harel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006702/
https://ncbi.nlm.nih.gov/pubmed/24785005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003603
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