The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

Neurotransmitter:sodium symporters (NSSs) in the SLC6 family terminate neurotransmission by coupling the thermodynamically favorable transport of ions to the thermodynamically unfavorable transport of neurotransmitter back into presynaptic neurons. Results from many structural, functional, and compu...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: LeVine, Michael V., Terry, Daniel S., Khelashvili, George, Siegel, Zarek S., Quick, Matthias, Javitch, Jonathan A., Blanchard, Scott C., Weinstein, Harel
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689989/
https://ncbi.nlm.nih.gov/pubmed/31324743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903020116
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