Two novel STK11 missense mutations induce phosphorylation of S6K and promote cell proliferation in Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease caused by mutations in serine threonine kinase 11 (STK11) and characterized by an increased risk of developing cancer. Inactivation of STK11 has been associated with the mammalian target of rapamycin (mTOR) pathway. Hyperactivation and phosph...

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Veröffentlicht in:Oncol Lett
Hauptverfasser: Li, Ran, Wang, Zhiqing, Liu, Shu, Wu, Baoping, Zeng, Di, Zhang, Yali, Gong, Lanbo, Deng, Feihong, Zheng, Haoxuan, Wang, Yadong, Chen, Chudi, Chen, Junsheng, Jiang, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772679/
https://ncbi.nlm.nih.gov/pubmed/29399144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7436
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