Two novel STK11 missense mutations induce phosphorylation of S6K and promote cell proliferation in Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease caused by mutations in serine threonine kinase 11 (STK11) and characterized by an increased risk of developing cancer. Inactivation of STK11 has been associated with the mammalian target of rapamycin (mTOR) pathway. Hyperactivation and phosph...

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Udgivet i:Oncol Lett
Main Authors: Li, Ran, Wang, Zhiqing, Liu, Shu, Wu, Baoping, Zeng, Di, Zhang, Yali, Gong, Lanbo, Deng, Feihong, Zheng, Haoxuan, Wang, Yadong, Chen, Chudi, Chen, Junsheng, Jiang, Bo
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772679/
https://ncbi.nlm.nih.gov/pubmed/29399144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.7436
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