∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

∆122p53 mice (a model of ∆133p53 isoform) are tumour-prone, have extensive inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed ∆122p53 mice with IL-6 null mice. Here we show that loss of IL-6 reduced JAK-STAT signalling, tumour incidence and metastasis. We also show that...

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Pubblicato in:Nat Commun
Autori principali: Campbell, Hamish, Fleming, Nicholas, Roth, Imogen, Mehta, Sunali, Wiles, Anna, Williams, Gail, Vennin, Claire, Arsic, Nikola, Parkin, Ashleigh, Pajic, Marina, Munro, Fran, McNoe, Les, Black, Michael, McCall, John, Slatter, Tania L., Timpson, Paul, Reddel, Roger, Roux, Pierre, Print, Cristin, Baird, Margaret A., Braithwaite, Antony W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772473/
https://ncbi.nlm.nih.gov/pubmed/29343721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02408-0
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