The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β isoform characterize prostate cancers with immune cell infiltration, particularly T cells and CD163+ macrophages. These can...

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Udgivet i:Cell Death Dis
Main Authors: Kazantseva, Marina, Mehta, Sunali, Eiholzer, Ramona A., Gimenez, Gregory, Bowie, Sara, Campbell, Hamish, Reily-Bell, Ashley L., Roth, Imogen, Ray, Sankalita, Drummond, Catherine J., Reid, Glen, Joruiz, Sebastien M., Wiles, Anna, Morrin, Helen R., Reader, Karen L., Hung, Noelyn A., Baird, Margaret A., Slatter, Tania L., Braithwaite, Antony W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702175/
https://ncbi.nlm.nih.gov/pubmed/31431617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1861-1
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