Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk

SIMPLE SUMMARY: We investigated the influence of genetic variants, called single nucleotide polymorphisms (SNP) in the TP53 tumour suppressor gene, on cancer risk, clinical features and TP53 isoform levels. These SNPs were significantly over-represented in cohorts of mixed cancers versus controls, s...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Eiholzer, Ramona A., Mehta, Sunali, Kazantseva, Marina, Drummond, Catherine J., McKinney, Cushla, Young, Katie, Slater, David, Morten, Brianna C., Avery-Kiejda, Kelly A., Lasham, Annette, Fleming, Nicholas, Morrin, Helen R., Reader, Karen, Royds, Janice A., Landmann, Michael, Petrich, Simone, Reddel, Roger, Huschtscha, Lily, Taha, Ahmad, Hung, Noelyn A., Slatter, Tania L., Braithwaite, Antony W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563340/
https://ncbi.nlm.nih.gov/pubmed/32882831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092472
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