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Alphaxalone Binds in Inner Transmembrane β(+)–α(−) Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors
BACKGROUND: Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants, amnestics, and sedative-hypnotics, effects linked to enhancement of GABA(A) receptor gating in the central nervous system. Data locating neurosteroid binding sites on synaptic αβγ GABA(A) receptors are sparse and inc...
Tallennettuna:
| Julkaisussa: | Anesthesiology |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771863/ https://ncbi.nlm.nih.gov/pubmed/29210709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001978 |
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