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Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Inter-subunit Sites for Four Intravenous Anesthetics and One Orphan Site
BACKGROUND: GABA(A) receptors mediate important effects of intravenous general anesthetics. Photolabel derivatives of etomidate, propofol, barbiturates, and a neurosteroid incorporate in GABA(A) receptor transmembrane helices M1 and M3 adjacent to inter-subunit pockets. However, photolabels have not...
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| Publicado no: | Anesthesiology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117677/ https://ncbi.nlm.nih.gov/pubmed/27753644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001390 |
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