Mutations at Beta N265 in γ-Aminobutyric Acid Type A Receptors Alter Both Binding Affinity and Efficacy of Potent Anesthetics

Etomidate and propofol are potent general anesthetics that act via GABAA receptor allosteric co-agonist sites located at transmembrane β+/α− inter-subunit interfaces. Early experiments in heteromeric receptors identified βN265 (M2-15′) on β2 and β3 subunits as an important determinant of sensitivity...

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Autores principales: Stewart, Deirdre S., Pierce, David W., Hotta, Mayo, Stern, Alex T., Forman, Stuart A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210246/
https://ncbi.nlm.nih.gov/pubmed/25347186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111470
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