Etomidate produces similar allosteric modulation in α1β3γ and α1β3γ2L GABA(A) receptors

BACKGROUND AND PURPOSE: Neuronal GABA(A) receptors are pentameric chloride ion channels, which include synaptic αβγ and extrasynaptic αβδ isoforms, mediating phasic and tonic inhibition respectively. Although the subunit arrangement of αβγ receptors is established as β-α-γ-β-α, that of αβδ receptors...

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Bibliografiska uppgifter
Huvudupphovsmän: Feng, H-J, Jounaidi, Y, Haburcak, M, Yang, X, Forman, S A
Materialtyp: Artigo
Språk:Inglês
Publicerad: British Journal of Pharmacology 2014
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969089/
https://ncbi.nlm.nih.gov/pubmed/24199598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12507
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