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Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice
Impaired resorption of cartilage matrix deposited during endochondral ossification is a defining feature of juvenile osteopetrosis. Growing, leptin-deficient ob/ob mice exhibit a mild form of osteopetrosis. However, the extent to which the disease is (1) self-limiting and (2) reversible by leptin tr...
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| Publicat a: | J Endocrinol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771473/ https://ncbi.nlm.nih.gov/pubmed/29191939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-17-0524 |
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