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Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice

Impaired resorption of cartilage matrix deposited during endochondral ossification is a defining feature of juvenile osteopetrosis. Growing, leptin-deficient ob/ob mice exhibit a mild form of osteopetrosis. However, the extent to which the disease is (1) self-limiting and (2) reversible by leptin tr...

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Bibliografske podrobnosti
izdano v:J Endocrinol
Main Authors: Philbrick, Kenneth A., Martin, Stephen A., Colagiovanni, Amy R., Branscum, Adam J., Turner, Russell T., Iwaniec, Urszula T.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771473/
https://ncbi.nlm.nih.gov/pubmed/29191939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-17-0524
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