A metabolic function of FGFR3-TACC3 gene fusions in cancer

Chromosomal translocations that generate in-frame oncogenic gene fusions are powerful examples of success of targeted cancer therapies(1–3). We discovered FGFR3-TACC3 (F3-T3) gene fusions in 3% of human glioblastoma(4). Subsequent studies reported similar frequencies of F3-T3 in many other cancers,...

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Publicado en:Nature
Main Authors: Frattini, Véronique, Pagnotta, Stefano M., Tala, Fan, Jerry J., Russo, Marco V., Lee, Sang Bae, Garofano, Luciano, Zhang, Jing, Shi, Peiguo, Lewis, Genevieve, Sanson, Heloise, Frederick, Vanessa, Castano, Angelica M., Cerulo, Luigi, Rolland, Delphine C. M., Mall, Raghvendra, Mokhtari, Karima, Elenitoba-Johnson, Kojo S.J., Sanson, Marc, Huang, Xi, Ceccarelli, Michele, Lasorella, Anna, Iavarone, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771419/
https://ncbi.nlm.nih.gov/pubmed/29323298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25171
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