A metabolic function of FGFR3-TACC3 gene fusions in cancer

Chromosomal translocations that generate in-frame oncogenic gene fusions are powerful examples of success of targeted cancer therapies(1–3). We discovered FGFR3-TACC3 (F3-T3) gene fusions in 3% of human glioblastoma(4). Subsequent studies reported similar frequencies of F3-T3 in many other cancers,...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Frattini, Véronique, Pagnotta, Stefano M., Tala, Fan, Jerry J., Russo, Marco V., Lee, Sang Bae, Garofano, Luciano, Zhang, Jing, Shi, Peiguo, Lewis, Genevieve, Sanson, Heloise, Frederick, Vanessa, Castano, Angelica M., Cerulo, Luigi, Rolland, Delphine C. M., Mall, Raghvendra, Mokhtari, Karima, Elenitoba-Johnson, Kojo S.J., Sanson, Marc, Huang, Xi, Ceccarelli, Michele, Lasorella, Anna, Iavarone, Antonio
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771419/
https://ncbi.nlm.nih.gov/pubmed/29323298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25171
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