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Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice

Progressive accumulation of highly phosphorylated tau protein isoforms is the main feature of a group of neurodegenerative diseases collectively called tauopathies. Data from human and animal models of these diseases have shown that neuroinflammation often accompanies their pathogenesis. The 5‐lipox...

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Vydáno v:Aging Cell
Hlavní autoři: Vagnozzi, Alana N., Giannopoulos, Phillip F., Praticò, Domenico
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771392/
https://ncbi.nlm.nih.gov/pubmed/29106033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12695
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