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Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice

The 5‐lipoxygenase (5LO) is a source of inflammatory leukotrienes and is upregulated in Alzheimer's disease and related tauopathies. However, whether it directly modulates tau phosphorylation and the development of its typical neuropathology in the absence of Aβ or is a secondary event during t...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Giannopoulos, Phillip F., Chiu, Jian, Praticò, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946065/
https://ncbi.nlm.nih.gov/pubmed/29607621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12759
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