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Pharmacologic inhibition of 5Lipoxygenase improves memory, rescues synaptic dysfunction and ameliorates tau pathology in a transgenic model of tauopathy
BACKGROUND: The 5-lipoxygenase (5LO) is a protein widely distributed in the central nervous system where modulates amyloidosis and memory impairments in transgenic mouse models of Alzheimer’s disease. However, no data are available as to whether 5LO is elevated in human tauopathy, or if it directly...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biol Psychiatry |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4529386/ https://ncbi.nlm.nih.gov/pubmed/25802082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.01.015 |
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