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5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of AD
OBJECTIVE: The 5-lipoxygenase (5LO) enzyme is up-regulated in Alzheimer’s disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated. METHODS: To this end, we generated triple transgenic mice (3xTg-AD) o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464917/ https://ncbi.nlm.nih.gov/pubmed/23034916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23642 |
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