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Allosteric Modulation of Intact γ-Secretase Structural Dynamics
As a protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of amyloid β fibrils implicated in Alzheimer's disease, γ-secretase is an important target for developing therapeutics against Alzheimer's disease. γ-secretase is composed of four subuni...
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| Published in: | Biophys J |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770568/ https://ncbi.nlm.nih.gov/pubmed/29262358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.012 |
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