Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

γ-Secretase is an intramembrane-cleaving protease responsible for the generation of amyloid-β (Aβ) peptides. Recently, a series of compounds called γ-secretase modulators (GSMs) has been shown to decrease the levels of long toxic Aβ species (i.e., Aβ42), with a concomitant elevation of the productio...

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Bibliographic Details
Main Authors: Takeo, Koji, Tanimura, Shun, Shinoda, Takehiro, Osawa, Satoko, Zahariev, Ivan Krasmirov, Takegami, Naoki, Ishizuka-Katsura, Yoshiko, Shinya, Naoko, Takagi-Niidome, Shizuka, Tominaga, Aya, Ohsawa, Noboru, Kimura-Someya, Tomomi, Shirouzu, Mikako, Yokoshima, Satoshi, Yokoyama, Shigeyuki, Fukuyama, Tohru, Tomita, Taisuke, Iwatsubo, Takeshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115564/
https://ncbi.nlm.nih.gov/pubmed/25009180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402171111
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