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Inferring joint sequence-structural determinants of protein functional specificity

Residues responsible for allostery, cooperativity, and other subtle but functionally important interactions remain difficult to detect. To aid such detection, we employ statistical inference based on the assumption that residues distinguishing a protein subgroup from evolutionarily divergent subgrou...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Neuwald, Andrew F, Aravind, L, Altschul, Stephen F
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770160/
https://ncbi.nlm.nih.gov/pubmed/29336305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29880
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