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Inferring joint sequence-structural determinants of protein functional specificity

Residues responsible for allostery, cooperativity, and other subtle but functionally important interactions remain difficult to detect. To aid such detection, we employ statistical inference based on the assumption that residues distinguishing a protein subgroup from evolutionarily divergent subgrou...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Neuwald, Andrew F, Aravind, L, Altschul, Stephen F
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770160/
https://ncbi.nlm.nih.gov/pubmed/29336305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29880
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