Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthrop...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Prow, Natalie A., Tang, Bing, Gardner, Joy, Le, Thuy T., Taylor, Adam, Poo, Yee S., Nakayama, Eri, Hirata, Thiago D. C., Nakaya, Helder I., Slonchak, Andrii, Mukhopadhyay, Pamela, Mahalingam, Suresh, Schroder, Wayne A., Klimstra, William, Suhrbier, Andreas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770078/
https://ncbi.nlm.nih.gov/pubmed/29281739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006788
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