Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthrop...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Prow, Natalie A., Tang, Bing, Gardner, Joy, Le, Thuy T., Taylor, Adam, Poo, Yee S., Nakayama, Eri, Hirata, Thiago D. C., Nakaya, Helder I., Slonchak, Andrii, Mukhopadhyay, Pamela, Mahalingam, Suresh, Schroder, Wayne A., Klimstra, William, Suhrbier, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770078/
https://ncbi.nlm.nih.gov/pubmed/29281739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006788
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