Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis

The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3 inflammasome represents a promising therapeutic for the tre...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Liu, Yi, Jing, Yan-Yun, Zeng, Chen-Ying, Li, Chen-Guang, Xu, Li-Hui, Yan, Liang, Bai, Wen-Jing, Zha, Qing-Bing, Ouyang, Dong-Yun, He, Xian-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767189/
https://ncbi.nlm.nih.gov/pubmed/29375379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00975
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