Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis

The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3 inflammasome represents a promising therapeutic for the tre...

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Bibliographische Detailangaben
Hauptverfasser: Yi Liu, Yan-Yun Jing, Chen-Ying Zeng, Chen-Guang Li, Li-Hui Xu, Liang Yan, Wen-Jing Bai, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-01-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
scutellarin
NLRP3 inflammasome
pyroptosis
protein kinase A
macrophages
Online Zugang:http://journal.frontiersin.org/article/10.3389/fphar.2017.00975/full
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