LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIC ASSAY FOR THE QUANTITATION OF THE NOVEL RADIATION PROTECTIVE AGENT AND RADIATION MITIGATOR JP4-039 IN MURINE PLASMA

JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50 μL plasma was followed by isocratic reverse phase...

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Detalhes bibliográficos
Publicado no:J Pharm Biomed Anal
Main Authors: Christner, Susan, Guo, Jianxia, Parise, Robert A., Ringeval, Melanie, Hoye, Adam T., Wipf, Peter, Epperly, Michael W., Greenberger, Joel S., Beumer, Jan H., Eiseman, Julie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767136/
https://ncbi.nlm.nih.gov/pubmed/29245086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2017.12.023
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