LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIC ASSAY FOR THE QUANTITATION OF THE NOVEL RADIATION PROTECTIVE AGENT AND RADIATION MITIGATOR JP4-039 IN MURINE PLASMA

JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50 μL plasma was followed by isocratic reverse phase...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharm Biomed Anal
Prif Awduron: Christner, Susan, Guo, Jianxia, Parise, Robert A., Ringeval, Melanie, Hoye, Adam T., Wipf, Peter, Epperly, Michael W., Greenberger, Joel S., Beumer, Jan H., Eiseman, Julie L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767136/
https://ncbi.nlm.nih.gov/pubmed/29245086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2017.12.023
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