Heart failure–induced activation of phospholipase iPLA(2)γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

Congestive heart failure typically arises from cardiac myocyte necrosis/apoptosis, associated with the pathological opening of the mitochondrial permeability transition pore (mPTP). mPTP opening decreases the mitochondrial membrane potential leading to the activation of Ca(2+)-independent phospholip...

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Publicat a:J Biol Chem
Autors principals: Moon, Sung Ho, Liu, Xinping, Cedars, Ari M., Yang, Kui, Kiebish, Michael A., Joseph, Susan M., Kelley, John, Jenkins, Christopher M., Gross, Richard W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766913/
https://ncbi.nlm.nih.gov/pubmed/29158256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000405
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