Genetic Ablation of Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) Attenuates Calcium-induced Opening of the Mitochondrial Permeability Transition Pore and Resultant Cytochrome c Release

Herein, we demonstrate that calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a critical mechanistic participant in the calcium-induced opening of the mitochondrial permeability transition pore (mPTP). Liver mitochondria from iPLA(2)γ(−/−) mice were markedly resistant to calcium-induced swelling...

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Bibliografische gegevens
Hoofdauteurs: Moon, Sung Ho, Jenkins, Christopher M., Kiebish, Michael A., Sims, Harold F., Mancuso, David J., Gross, Richard W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Bioenergetics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436185/
https://ncbi.nlm.nih.gov/pubmed/22778252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.373654
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