Activation of Mitochondrial Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) by Divalent Cations Mediating Arachidonate Release and Production of Downstream Eicosanoids

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) (PNPLA8) is the predominant phospholipase activity in mammalian mitochondria. However, the chemical mechanisms that regulate its activity are unknown. Here, we utilize iPLA(2)γ gain of function and loss of function genetic models to demonstrate the...

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Detalhes bibliográficos
Main Authors: Moon, Sung Ho, Jenkins, Christopher M., Liu, Xinping, Guan, Shaoping, Mancuso, David J., Gross, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340231/
https://ncbi.nlm.nih.gov/pubmed/22389508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336776
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