Activation of Mitochondrial Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) by Divalent Cations Mediating Arachidonate Release and Production of Downstream Eicosanoids

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) (PNPLA8) is the predominant phospholipase activity in mammalian mitochondria. However, the chemical mechanisms that regulate its activity are unknown. Here, we utilize iPLA(2)γ gain of function and loss of function genetic models to demonstrate the...

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Bibliografiset tiedot
Päätekijät: Moon, Sung Ho, Jenkins, Christopher M., Liu, Xinping, Guan, Shaoping, Mancuso, David J., Gross, Richard W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340231/
https://ncbi.nlm.nih.gov/pubmed/22389508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336776
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