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Activation of Mitochondrial Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) by Divalent Cations Mediating Arachidonate Release and Production of Downstream Eicosanoids
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) (PNPLA8) is the predominant phospholipase activity in mammalian mitochondria. However, the chemical mechanisms that regulate its activity are unknown. Here, we utilize iPLA(2)γ gain of function and loss of function genetic models to demonstrate the...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340231/ https://ncbi.nlm.nih.gov/pubmed/22389508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336776 |
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