12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA(2)γ knockout

The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A(2)-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosanoid products. However, recent work has demonstrated that the major phospholipase in...

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Опубликовано в: :J Biol Chem
Главные авторы: Liu, Xinping, Sims, Harold F., Jenkins, Christopher M., Guan, Shaoping, Dilthey, Beverly G., Gross, Richard W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170522/
https://ncbi.nlm.nih.gov/pubmed/32161117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012296
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