Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids in myocardium. To specifically identify the rol...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Moon, Sung Ho, Mancuso, David J., Sims, Harold F., Liu, Xinping, Nguyen, Annie L., Yang, Kui, Guan, Shaoping, Dilthey, Beverly Gibson, Jenkins, Christopher M., Weinheimer, Carla J., Kovacs, Attila, Abendschein, Dana, Gross, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016701/
https://ncbi.nlm.nih.gov/pubmed/27453526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740597
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