Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids in myocardium. To specifically identify the rol...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Moon, Sung Ho, Mancuso, David J., Sims, Harold F., Liu, Xinping, Nguyen, Annie L., Yang, Kui, Guan, Shaoping, Dilthey, Beverly Gibson, Jenkins, Christopher M., Weinheimer, Carla J., Kovacs, Attila, Abendschein, Dana, Gross, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016701/
https://ncbi.nlm.nih.gov/pubmed/27453526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740597
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