Activation of Mitochondrial Calcium-independent Phospholipase A(2)γ (iPLA(2)γ) by Divalent Cations Mediating Arachidonate Release and Production of Downstream Eicosanoids

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) (PNPLA8) is the predominant phospholipase activity in mammalian mitochondria. However, the chemical mechanisms that regulate its activity are unknown. Here, we utilize iPLA(2)γ gain of function and loss of function genetic models to demonstrate the...

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Bibliographic Details
Main Authors: Moon, Sung Ho, Jenkins, Christopher M., Liu, Xinping, Guan, Shaoping, Mancuso, David J., Gross, Richard W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340231/
https://ncbi.nlm.nih.gov/pubmed/22389508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336776
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