Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials

BACKGROUND: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (D...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bastiaens, Guido J. H., Tiono, Alfred B., Okebe, Joseph, Pett, Helmi E., Coulibaly, Sam A., Gonçalves, Bronner P., Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C., Sanou, Guillaume S., Nébié, Issa, Bradley, John, Lanke, Kjerstin H. W., Niemi, Mikko, Sirima, Sodiomon B., d’Alessandro, Umberto, Bousema, Teun, Drakeley, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764271/
https://ncbi.nlm.nih.gov/pubmed/29324864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190272
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