CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum

Single-dose primaquine (PQ) clears mature gametocytes and reduces the transmission of Plasmodium falciparum after artemisinin combination therapy. Genetic variation in CYP2D6, the gene producing the drug-metabolizing enzyme cytochrome P450 2D6 (CYP2D6), influences plasma concentrations of PQ and its...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Pett, Helmi, Bradley, John, Okebe, Joseph, Dicko, Alassane, Tiono, Alfred B., Gonçalves, Bronner P., Stone, Will, Chen, Ingrid, Lanke, Kjerstin, Neuvonen, Mikko, Mustaniemi, Anna-Liina, Eziefula, Alice C., Gosling, Roly, D’Alessandro, Umberto, Drakeley, Chris, Niemi, Mikko, Bousema, Teun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761544/
https://ncbi.nlm.nih.gov/pubmed/31383656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00538-19
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