G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials

Primaquine (PQ) is an antimalarial drug with the potential to reduce malaria transmission due to its capacity to clear mature Plasmodium falciparum gametocytes in the human host. However, the large-scale roll-out of PQ has to be counterbalanced by the additional risk of drug-induced hemolysis in ind...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Sepúlveda, Nuno, Grignard, Lynn, Curry, Jonathan, Mahey, Laleta, Bastiaens, Guido J. H., Tiono, Alfred B., Okebe, Joseph, Coulibaly, Sam A., Gonçalves, Bronner P., Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C., Sanou, Guillaume S., Nébié, Issa, Lanke, Kjerstin, Sirima, Sodiomon B., Dicko, Alassane, d’Alessandro, Umberto, Clark, Taane G., Campino, Susana, Chen, Ingrid, Eziefula, Alice C., Gosling, Roly, Bousema, Teun, Drakeley, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062977/
https://ncbi.nlm.nih.gov/pubmed/33897764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.645688
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