G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials

Primaquine (PQ) is an antimalarial drug with the potential to reduce malaria transmission due to its capacity to clear mature Plasmodium falciparum gametocytes in the human host. However, the large-scale roll-out of PQ has to be counterbalanced by the additional risk of drug-induced hemolysis in ind...

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Foilsithe in:Front Genet
Main Authors: Sepúlveda, Nuno, Grignard, Lynn, Curry, Jonathan, Mahey, Laleta, Bastiaens, Guido J. H., Tiono, Alfred B., Okebe, Joseph, Coulibaly, Sam A., Gonçalves, Bronner P., Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C., Sanou, Guillaume S., Nébié, Issa, Lanke, Kjerstin, Sirima, Sodiomon B., Dicko, Alassane, d’Alessandro, Umberto, Clark, Taane G., Campino, Susana, Chen, Ingrid, Eziefula, Alice C., Gosling, Roly, Bousema, Teun, Drakeley, Chris
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Genetics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062977/
https://ncbi.nlm.nih.gov/pubmed/33897764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.645688
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