High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines

Hepatofibrosis, which leads to cirrhosis and eventual hepatocellular carcinoma, is a common response to chronic toxin-mediated liver injury. Nitrosamines are potent hepatotoxic agents that cause necrosis and subsequent fibrosis in the liver as a result of cytochrome P450 2E1 (CYP2E1)-dependent metab...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Gao, Jie, Wang, Gao-Ju, Wang, Zhao, Gao, Na, Li, Jing, Zhang, Yun-Fei, Zhou, Jun, Zhang, Hong-Xin, Wen, Qiang, Jin, Han, Qiao, Hai-Ling
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper: Gerotarget (Focus on Aging)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762503/
https://ncbi.nlm.nih.gov/pubmed/29348818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22937
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