Contribution of Baicalin on the Plasma Protein Binding Displacement and CYP3A Activity Inhibition to the Pharmacokinetic Changes of Nifedipine in Rats In Vivo and In Vitro

Baicalin purified from the root of Radix scutellariae is widely used in clinical practices. This study aimed to evaluate the effect of baicalin on the pharmacokinetics of nifedipine, a CYP3A probe substrate, in rats in vivo and in vitro. In a randomised, three-period crossover study, significant cha...

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Bibliographic Details
Main Authors: Cheng, Zhen-Yu, Tian, Xin, Gao, Jie, Li, Hong-Meng, Jia, Lin-Jing, Qiao, Hai-Ling
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907542/
https://ncbi.nlm.nih.gov/pubmed/24498050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087234
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