Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach

Hepatocellular carcinoma (HCC) accompanied by severe liver dysfunction is a serious disease, which results in altered hepatic clearance. Generally, maintenance doses depend upon drug clearance, so individual dosage regimens should be customized for HCC patients based on the condition of patients. Ba...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Gao, Jie, Zhou, Jun, He, Xiao-Pei, Zhang, Yun-Fei, Gao, Na, Tian, Xin, Fang, Yan, Wen, Qiang, Jia, Lin-Jing, Jin, Han, Qiao, Hai-Ling
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053749/
https://ncbi.nlm.nih.gov/pubmed/27086920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8704
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