Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach

Hepatocellular carcinoma (HCC) accompanied by severe liver dysfunction is a serious disease, which results in altered hepatic clearance. Generally, maintenance doses depend upon drug clearance, so individual dosage regimens should be customized for HCC patients based on the condition of patients. Ba...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Gao, Jie, Zhou, Jun, He, Xiao-Pei, Zhang, Yun-Fei, Gao, Na, Tian, Xin, Fang, Yan, Wen, Qiang, Jia, Lin-Jing, Jin, Han, Qiao, Hai-Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053749/
https://ncbi.nlm.nih.gov/pubmed/27086920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8704
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