Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach

Hepatocellular carcinoma (HCC) accompanied by severe liver dysfunction is a serious disease, which results in altered hepatic clearance. Generally, maintenance doses depend upon drug clearance, so individual dosage regimens should be customized for HCC patients based on the condition of patients. Ba...

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Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Gao, Jie, Zhou, Jun, He, Xiao-Pei, Zhang, Yun-Fei, Gao, Na, Tian, Xin, Fang, Yan, Wen, Qiang, Jia, Lin-Jing, Jin, Han, Qiao, Hai-Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053749/
https://ncbi.nlm.nih.gov/pubmed/27086920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8704
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